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System dostarczania leków oparty na nanowłóknach stosowany w leczeniu leiszmaniozy

System dostarczania leków oparty na nanowłóknach stosowany w leczeniu leiszmaniozy

Himansu Sekhar Nanda / Narayan Chandra Mishra / R. Jayaganthan

73,20 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Tecnología: cuestiones generales
ISBN:
9786209910876
73,20 €
IVA incluido
Disponible

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W celu opracowania nowatorskiego systemu dostarczania leków przygotowano biodegradowalne nanowłókna zawierające amfoterycynę B, która jest najbardziej obiecującym lekiem stosowanym w leczeniu leiszmaniozy. Degradowalne nanowłókna przygotowano z 10% wag. żelatyny w kwasie octowym i wodzie zmieszanej z 1% wag. amfoterycyny B, a morfologię włókien zbadano za pomocą skaningowego mikroskopu elektronowego z emisją polową (FE-SEM). W optymalnych warunkach procesu zaobserwowano tworzenie się włókien bez kulek o średniej średnicy 100 nm. Integralność chemiczną leku w nanowłóknach elektroprzędzonych potwierdzono za pomocą analizy spektroskopowej w podczerwieni z transformacją Fouriera (FTIR). Uwalnianie amfoterycyny B z nanowłókien badano za pomocą spektrofotometru UV-Vis w buforze fosforanowym o pH 7,4 w normalnej temperaturze fizjologicznej ciała wynoszącej 37 °C. Zaobserwowano kontrolowany przebieg uwalniania amfoterycyny B z nanowłókien żelatynowych, co sugeruje, że elektroprzędzone biodegradowalne nanowłókna zawierające amfoterycynę B są bardzo obiecujące w leczeniu leiszmaniozy.

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