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Synteza wzorca wewnętrznego dla bikalutamidu

Synteza wzorca wewnętrznego dla bikalutamidu

Jan van der Westhuizen / Maryam Amra Jordaan

81,67 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Química
ISBN:
9786208908850
81,67 €
IVA incluido
Disponible

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Sobre IBD

(R,S)-Bikalutamid [N-(4-cyjano-3-trifluorometylofenylo)-α-metylo-α-hydroksy-β-(4- fluorofenylosulfonylo)propanamid], sprzedawany jako Casodex®, jest wiodącym antyandrogenem stosowanym obecnie w leczeniu raka prostaty. Wiąże się on z receptorami androgenowymi i blokuje wzrost nowotworu. Prace te mają na celu opracowanie wewnętrznych standardów dla bioanalitycznego komponentu badań klinicznych, które są wymagane do wykrywania bikalutamidu i jego pochodnych. Wzorzec wewnętrzny jest dodawany do próbki płynu ustrojowego (głównie krwi) na początku pracy z próbką w przybliżeniu w tym samym stężeniu analitu, który ma być oznaczony ilościowo. Idealny wzorzec wewnętrzny ma podobny odzysk po ekstrakcji i podobny czas retencji w HPLC. W przypadku oznaczania ilościowego za pomocą spektrometrii mas powinien mieć różnicę co najmniej 3 jednostek masy w stosunku do analitu i podobną reakcję jonizacji. Wzorzec wewnętrzny służy do kalibracji całkowitego prądu jonowego metabolitu.

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