Inicio > Matemáticas y ciencia > Química > Sintesi di uno standard interno per la bicalutamide
Sintesi di uno standard interno per la bicalutamide

Sintesi di uno standard interno per la bicalutamide

Jan van der Westhuizen / Maryam Amra Jordaan

81,67 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Química
ISBN:
9786208908928
81,67 €
IVA incluido
Disponible

Selecciona una librería:

  • Librería Samer Atenea
  • Librería Aciertas (Toledo)
  • Kálamo Books
  • Librería Perelló (Valencia)
  • Librería Elías (Asturias)
  • Donde los libros
  • Librería Kolima (Madrid)
  • Librería Proteo (Málaga)
Sobre IBD

La (R,S)-bicalutamide [N-(4-ciano-3-trifluorometilfenile)-α-metil-α-idrossi-β-(4-fluorofenilsulfonil)propanamide], venduta come Casodex®, è il principale antiandrogeno attualmente utilizzato per il trattamento del cancro alla prostata. Si lega ai recettori degli androgeni e blocca la crescita del cancro. Questo lavoro mira a sviluppare standard interni per la componente bio-analitica degli studi clinici che devono rilevare la bicalutamide e i suoi derivati. Uno standard interno viene aggiunto al campione di fluido corporeo (per lo più sangue) all’inizio del work up del campione alla stessa concentrazione dell’analita da quantificare. Uno standard interno ideale ha un recupero di estrazione simile e un tempo di ritenzione simile in HPLC. Per la quantificazione con la spettrometria di massa deve avere una differenza di almeno 3 unità di massa rispetto all’analita e una risposta di ionizzazione simile. Lo standard interno viene utilizzato per calibrare la corrente ionica totale del metabolita.

Artículos relacionados

  • Suzuki-Miyaura Cross-Coupling Reaction and Potential Applications
    Suzuki–Miyaura cross-coupling remains a powerful tool in organic synthesis for C–C bond formation and has various industrial applications, for example, the synthesis of pharmaceuticals and materials. Intensive research efforts are being made into finding ways of improving and expanding the scope of this process, and the development of more efficient catalytic systems for this e...
    Disponible

    67,89 €

  • Catalysis for Low Temperature Fuel Cells
    Today, the development of active and stable catalysts still represents a challenge to overcome in the research field of low temperature fuel cells. Operation at low temperatures demands the utilization of highly active catalysts to reduce the activation energy of the electrochemical reactions involved at the electrodes, and thus obtain practical performances and high efficienci...
    Disponible

    59,74 €

  • Trends in Microextraction Techniques for Sample Preparation
    Micro-extraction techniques in sample preparation are gaining interest among analytical chemists as they comply with green analytical chemistry demands and ensure environmental protection and public safety. Savings in cost and time are considered as valuable benefits by using novel micro-extraction approaches in sample handling. Selectivity, sensitivity and lower detection limi...
    Disponible

    59,87 €

  • Advances and Applications of Nano-antimicrobial Treatments
    Nowadays, great concerns are associated with the resistance demonstrated by many microorganisms towards the conventional antibiotic therapies. The failure of traditional antimicrobials, and the increasing healthcare costs, have encouraged scientific research and the development of novel antimicrobial agents. Particularly, there is a great deal of interest in nanotechnologies an...
    Disponible

    51,68 €

  • Handbook of Research on Uncovering New Methods for Ecosystem Management through Bioremediation
    Kajal Srivastava / Shivom Singh
    Maintaining and preserving the environment is a crucial consideration in an era where climate change and rising sea levels are common knowledge. It is important for researchers and developers alike to explore potential solutions for a steadily warming world. The Handbook of Research on Uncovering New Methods for Ecosystem Management through Bioremediation focuses on the agricul...
  • Structural Design and Properties of Coordination Polymers
    The assembly of organic ligands and metal centres yields coordination polymers, many of which find applications in conductivity, catalysis, magnetism, gas sorption, biological sensing and luminescence. The structure and topology of coordination polymers may be manipulated by changing the reaction conditions, leading to a large variety of structurally and topologically unique pr...
    Disponible

    43,77 €

Otros libros del autor

  • Die Synthese eines internen Standards für Bicalutamid
    Jan van der Westhuizen / Maryam Amra Jordaan
    (R,S)-Bicalutamid [N-(4-Cyano-3-trifluormethylphenyl)-α-methyl-α-hydroxy-β-(4-fluorphenylsulfonyl)propanamid], verkauft als Casodex®, ist das führende Antiandrogen, das derzeit zur Behandlung von Prostatakrebs eingesetzt wird. Es bindet sich an die Androgenrezeptoren und blockiert das Krebswachstum. Ziel dieser Arbeit ist die Entwicklung interner Standards für die bioanalytisch...
    Disponible

    81,67 €

  • Synthèse d’un étalon interne pour le bicalutamide
    Jan van der Westhuizen / Maryam Amra Jordaan
    Le (R,S)-Bicalutamide [N-(4-cyano-3-trifluorométhylphényl)-α-méthyl-α-hydroxy-β-(4- fluorophénylsulfonyl)propanamide], vendu sous le nom de Casodex®, est le principal antiandrogène actuellement utilisé pour traiter le cancer de la prostate. Il se lie aux récepteurs androgènes et bloque la croissance du cancer. Ce travail vise à développer des étalons internes pour la composante...
    Disponible

    81,67 €

  • Síntese de um padrão interno para a bicalutamida
    Jan van der Westhuizen / Maryam Amra Jordaan
    (R,S)-Bicalutamida [N-(4-cyano-3-trifluoromethylphenyl)-α-methyl-α-hydroxy-β-(4- fluorophenylsulfonyl)propanamide], vendida como Casodex®, é o principal antiandrogénio atualmente utilizado para tratar o cancro da próstata. Liga-se aos receptores de androgénio e bloqueia o crescimento do cancro. Este trabalho tem como objetivo desenvolver padrões internos para a componente bioan...
    Disponible

    81,67 €

  • Synteza wzorca wewnętrznego dla bikalutamidu
    Jan van der Westhuizen / Maryam Amra Jordaan
    (R,S)-Bikalutamid [N-(4-cyjano-3-trifluorometylofenylo)-α-metylo-α-hydroksy-β-(4- fluorofenylosulfonylo)propanamid], sprzedawany jako Casodex®, jest wiodącym antyandrogenem stosowanym obecnie w leczeniu raka prostaty. Wiąże się on z receptorami androgenowymi i blokuje wzrost nowotworu. Prace te mają na celu opracowanie wewnętrznych standardów dla bioanalitycznego komponentu bad...
    Disponible

    81,67 €