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Sviluppo di un nuovo idrogel per la rigenerazione cutanea

Sviluppo di un nuovo idrogel per la rigenerazione cutanea

Ilídio Correia / Maximiano Ribeiro / Sónia Miguel

99,96 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630374841
99,96 €
IVA incluido
Disponible

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Le lesioni cutanee sono eventi traumatici che comportano un aumento della perdita di liquidi, infezioni, formazione di cicatrici e la comparsa di aree immunocompromesse. La perdita dell’integrità cutanea può causare significativi squilibri fisiologici, disabilità o addirittura la morte. Finora sono state sviluppate diverse medicazioni per le ferite. Tra queste, gli idrogel sono quelli più utilizzati. Nel presente studio è stato prodotto un idrogel termoresponsivo utilizzando chitosano e agarosio, formato a temperatura corporea (37 °C), al fine di verificarne l’applicabilità nel trattamento delle ferite. L’attività battericida, la biocompatibilità, la morfologia, la porosità e la bagnabilità dell’idrogel sono state caratterizzate mediante microscopia confocale, saggio MTS e SEM. I risultati ottenuti hanno rivelato che l’idrogel presenta una dimensione dei pori (90-400 µm) compatibile con l’internalizzazione e la proliferazione cellulare. È stata osservata un’attività battericida per gli idrogel contenenti più di 188 µg/mL di chitosano. I risultati ottenuti hanno dimostrato che questa rete tridimensionale possiede le proprietà adeguate per migliorare il processo di guarigione delle ferite cutanee.

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