Studie

Studie

Diana Isabella Dmytrow

51,82 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9783639630862
51,82 €
IVA incluido
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Die Zielsetzung dieser Studie ist die empirische Untersuchung der Häufigkeit der simultan applizierten CYP3A-Inhibitoren in der klinischen Routine. Als Methode wird eine retrospektive und anonymisierte Erhebung gewählt. Die Analyse ergab folgende Ergebnisse: Es waren 8,57% stationäre Patiententage (27 von 315) und 8,33% Patienten (4 von 48) der simultanen Applikation von CYP3A-Inhibitoren ausgesetzt. Bei der Diagnose AML ist die Häufigkeit der simultan applizierten CYP3A-Inhibitoren auffallend hoch, da hierbei überdurchschnittlich viele, nämlich 0,379 CYP3A-Inhibitoren pro Tag, simultan appliziert wurden. Im Vergleich dazu haben NSCLC- nur 0,053 und SCLC-Patienten nur 0,091 CYP3A-Inhibitoren simultan pro Tag appliziert bekommen.Der Verdacht, dass Patienten mit einer AML eine höhere Wahrscheinlichkeit haben, CYP3A Inhibitoren an stationären Tagen appliziert zu bekommen, als alle anderen Patienten, wurde durch den Hypothesentest Chi-Quadrat (χ²), den Phi-Koeffizienten (ɸ) und den Cramer´s-V-Index (CI) untersucht und hat sich als Signifikant erwiesen.

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  • Jednoczesne stosowanie inhibitorów CYP w AML
    Diana Isabella Dmytrow
    Retrospektywne badanie kliniczno-kontrolne przeprowadzone na wcześniej wybranej grupie n = 108 pacjentów z rozpoznaniem AML, hospitalizowanych w niemieckim szpitalu. U 59 ze 108 pacjentów z AML (54,6%) stwierdzono jednoczesne stosowanie inhibitorów CYP. 59 pacjentów z AML doświadczyło znacznie więcej (p = 0,036) zdarzeń niepożądanych (1489 z 2483, 59,9%) niż pacjenci z AML bez ...
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  • Aplicação simultânea de inibidores do CYP na LMA
    Diana Isabella Dmytrow
    Estudo retrospectivo de caso-controlo em n = 108 pacientes previamente calculados com diagnóstico de LMA, durante uma internação num hospital alemão. Foi observada a aplicação simultânea de inibidores do CYP em 59 dos 108 doentes com LMA (54,6 %). 59 doentes com LMA sofreram significativamente mais (p = 0,036) eventos indesejáveis (1489 de 2483, 59,9 %) do que os doentes com LM...
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  • Study
    Diana Isabella Dmytrow
    The objective of this study is the empirical investigation of the frequency of simultaneously applied CYP3A inhibitors in clinical routine. A retrospective and anonymized survey was chosen as the method. The analysis yielded the following results: 8.57% inpatient days (27 of 315) and 8.33% patients (4 of 48) were exposed to simultaneous application of CYP3A inhibitors. The freq...
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