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STUDIE DER HBB-GEN-HAPLOTYPEN BEI VENEZOLANISCHEN SCHULKINDERN

STUDIE DER HBB-GEN-HAPLOTYPEN BEI VENEZOLANISCHEN SCHULKINDERN

EMIRJES MAZA

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208577858
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Sobre IBD

Eine Studie über die Häufigkeit von Hämoglobinopathien und Haplotypen des HBB-Gens wurde in den Städten Araya und Manicuare, Gemeinde Cruz Salmerón Acosta, Staat Sucre, durchgeführt. In beiden Populationen wurden insgesamt 289 periphere Blutproben von Schulkindern analysiert. 132 periphere Blutproben wurden nach dem Zufallsprinzip in der Bevölkerung von Araya und 157 Proben in Manicuare entnommen. Die hämatologischen Parameter (Hb, Hcto, CHCM, VCM, HCM) wurden mit einem automatischen hämatologischen Analysegerät untersucht. Die peripheren Blutproben wurden anschließend durch Elektrophorese auf Zelluloseacetatmembranen bei pH 8,6 analysiert, um die bei den Schulkindern vorhandenen Hämoglobinvarianten zu identifizieren. Dabei wurden 6,2 % (n=18) der Hämoglobinvarianten bei nicht verwandten Personen und 93,8 % (n=289) der Personen, die homozygot für Hb A waren, festgestellt.

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