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Stereochemical Aspects of Drug Action and Disposition

Stereochemical Aspects of Drug Action and Disposition

 

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Editorial:
Springer Nature B.V.
Año de edición:
2003
Materia
Farmacología
ISBN:
9783540415930

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Preface.- Section 1. Chemical Aspects: 1. Recent Developments in Asymmetric Organic Synthesis:Principles and Examples. 2. Stereoselective separations: Recent Advances in Capillary Electrophoresis and High-Performance Liquid Chromatography. 3. Stereochemical Issues in Bioactive Natural Products. 4. Drug Racemization and Its Significance in Pharmaceutical Research. 5. Physical Properties and Crystal Structures of Chiral Drugs.- Section 2. Experimental Pharmacology.- 6. Chiral Recognition in Biochemical Pharmacology: An Overview. 7. Enantioselectivity in Drug-Receptor Interactions. 8. Mechanisms of Stereoselective Binding to Functional Proteins. 9. Stereoselective Drug-Channel Interactions. 10. Toxocilogical Aspects.- Section 3. Drug Absorption, Distribution, Metabolism, Elimination: 11. Enantioselective GI Absorption:The Role of Transporters. 12. Enentioselective Plasma and Tissue Binding. 13. Stereoselective Drug Metabolism and Drug Interactions. 14. Metabolic Chiral Inversion of 2-Arylpropionic Acids. 15. Stereoselective Renal Elimination.- Section 4. Implications for Drug Development and Therapy: 16. Regulatory Requirements for the Development of Chirally Active Drugs. 17. Improving Clinical Risk / Benefit Through Stereochemistry.-

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