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Riparazione dei mismatch del DNA e sistema di checkpoint durante la meiosi

Riparazione dei mismatch del DNA e sistema di checkpoint durante la meiosi

Lin Sun

73,38 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786209977237
73,38 €
IVA incluido
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Sobre IBD

La T. thermophila è un ottimo organismo modello per la ricerca sulla riparazione dei mismatch del DNA (MMR). Il suo 'grande' corpo unicellulare facilita l’osservazione dei cambiamenti a livello cromosomico. La sua coniugazione (accoppiamento) è inducibile, il che rappresenta un vantaggio per lo studio delle funzioni proteiche durante la meiosi. L’MMR aumenta la fedeltà della replicazione del DNA. I sistemi di checkpoint mantengono l’integrità genomica all’interno del ciclo cellulare. Se si è accumulato un certo livello di danno al DNA a causa del processo di replicazione o di agenti che danneggiano il DNA, il ciclo cellulare viene arrestato per consentire il controllo e la riparazione del danno. Esistono checkpoint mitotici e checkpoint meiotici. Tuttavia, il meccanismo dei sistemi di checkpoint meiotici è ancora incerto. In questo libro, la relazione tra il checkpoint meiotico e la riparazione dei mismatch del DNA (MMR) è stata studiata in T. thermophila, il che è interessante per comprendere il sistema di checkpoint meiotico negli eucarioti.

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