Inicio > Matemáticas y ciencia > Química > Química física > Pochodne pirymidyny jako inhibitory ludzkiego receptora σ1
Pochodne pirymidyny jako inhibitory ludzkiego receptora σ1

Pochodne pirymidyny jako inhibitory ludzkiego receptora σ1

Fattouche Maroua

75,87 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Química física
ISBN:
9786200822222
75,87 €
IVA incluido
Disponible

Selecciona una librería:

  • Librería Samer Atenea
  • Librería Aciertas (Toledo)
  • Kálamo Books
  • Librería Perelló (Valencia)
  • Librería Elías (Asturias)
  • Donde los libros
  • Librería Kolima (Madrid)
  • Librería Proteo (Málaga)
Sobre IBD

Zespół bólu neuropatycznego wywiera znacząco szkodliwy i niepokojący wpływ na jakość życia dotkniętych nim osób. Aby ustalić skuteczną metodę leczenia tej dolegliwości, kompleksowe badania naukowe wykazały, że receptor sigma 1 stanowi niezwykły cel dla środków terapeutycznych. Analizy 3D-QSAR zostały przeprowadzone z wykorzystaniem metodologii Comparative Molecular Similarity Index Analysis (CoMSIA). Wyniki tych badań potwierdziły solidność struktury CoMSIA w precyzyjnym prognozowaniu bioaktywności różnorodnych związków. W sumie zsyntetyzowano szesnaście nowych związków, które wykazały zwiększoną skuteczność w zwalczaniu bólu neuropatycznego. W połączeniu z kompleksową analizą 3D-QSAR, nowo zsyntetyzowane związki poddano dokładnej ocenie mającej na celu wyjaśnienie ich profili farmakokinetycznych i toksykologicznych, uzyskując w ten sposób krytyczny wgląd w przyszłe badania in vitro.

Artículos relacionados

  • MARIE SKLODOWSKA CURIE
    Irina Rodica Rabeja
    Marie Sklodowska Curie (7 November 1867 – 4 July 1934) was one of the greatest scientific minds that brought a fundamental contribution in science opening the door to the understanding/knowledge of the structure of the atom in the 20th century.                 Marie Sklodowska Curie’s hypothesis that the spontaneous emission of powerful rays by some chemical elements, emission ...
    Disponible

    89,28 €

  • COMPUTER SIMULATIONS OF MOLECULES AND CONDENSED MATTER
    En-Ge Wang / LI XIN-ZHENG / Xin-Zheng Li / XIN-ZHENG LI & EN-GE WANG
    This book provides a relatively complete introduction to the methods used in computational condensed matter. A wide range of electronic structure theories are introduced, including traditional quantum chemistry methods, density functional theory, many-body perturbation theory, and more. Molecular dynamics simulations are also discussed, with extensions to enhanced sampling and ...
  • APPLIED THEORETICAL ORGANIC CHEMISTRY
    DEAN J TANTILLO / TANTILLO DEAN J
    This book provides state-of-the-art information on how studies in applied theoretical organic chemistry are conducted. It highlights the many approaches and tools available to those interested in using computational chemistry to predict and rationalize structures and reactivity of organic molecules. Chapters not only describe theoretical techniques in detail, but also describe ...
  • ELECTROANALYTICAL METHODS
    S Rani
    'Electroanalytical Methods' is a pivotal text that offers a comprehensive exploration of electrochemistry and its numerous applications across a wide array of scientific disciplines, including earth science, life science, physical science, biochemistry, and pharmaceutical chemistry. This book is an invaluable resource for chemistry graduates, underlining the increasing necessit...
    Disponible

    18,75 €

  • Advances in the Preparation, Properties and Application of Polyurethane, Cellulose and Their Composites
    Due to their excellent properties, polyurethane, cellulose and their composites have become widely used in previously unimagined areas. Given the fast-increasing consumption in recent years, the demand for advanced polyurethane- and cellulose-based composites is rapidly growing. Accordingly, this Special Issue seeks to showcase research papers, short communications and review a...
  • QUANTUM FIELD THEORY
    PORTER RICHARD N / RICHARD N PORTER
    This introduction to quantum field theory (QFT) is written by a physical chemist for physical chemists, chemical physicists, and other non-physicists with knowledge of quantum theory but who want to explore ways in which they might use the power of QFT in their investigations. This book starts where many graduate courses in quantum theory that are offered to chemistry students ...

Otros libros del autor

  • Dérivés de pyrimidine comme inhibiteurs des récepteurs σ1 humains
    Fattouche Maroua
    Le syndrome de la douleur neuropathique exerce une influence délétère et pénible sur la qualité de vie des personnes touchées. Afin de trouver une modalité de traitement efficace pour cette affection, des recherches scientifiques approfondies ont élucidé que le récepteur sigma 1 représente une cible remarquable pour les agents thérapeutiques. Les analyses 3D-QSAR ont été réalis...
    Disponible

    75,87 €

  • Derivati pirimidinici come inibitori del recettore σ1 umano
    Fattouche Maroua
    La sindrome del dolore neuropatico esercita un’influenza significativamente deleteria e angosciante sulla qualità della vita degli individui colpiti. Al fine di individuare una modalità di trattamento efficace per questo disturbo, studi scientifici approfonditi hanno chiarito che il recettore sigma 1 rappresenta un bersaglio notevole per gli agenti terapeutici. Le analisi 3D-QS...
    Disponible

    75,87 €

  • Pyrimidin-Derivate als menschliche σ1-Rezeptor-Hemmer
    Fattouche Maroua
    Das neuropathische Schmerzsyndrom beeinträchtigt die Lebensqualität der betroffenen Personen erheblich. Um eine wirksame Behandlungsmethode für dieses Leiden zu finden, haben umfassende wissenschaftliche Untersuchungen ergeben, dass der Sigma-1-Rezeptor ein bemerkenswertes Ziel für therapeutische Wirkstoffe darstellt. Die 3D-QSAR-Analysen wurden mit Hilfe der Comparative Molecu...
    Disponible

    75,87 €

  • Derivados da pirimidina como inibidores do recetor σ1 humano
    Fattouche Maroua
    A síndrome da dor neuropática exerce uma influência significativamente deletéria e angustiante na qualidade de vida dos indivíduos afectados. Para determinar uma modalidade de tratamento eficaz para esta doença, investigações científicas exaustivas elucidaram que o recetor sigma 1 representa um alvo notável para agentes terapêuticos. As análises 3D-QSAR foram efectuadas utiliza...
    Disponible

    75,87 €

  • Pyrimidine derivatives as human σ1 receptor inhibitors
    Fattouche Maroua
    Neuropathic pain syndrome exerts a significantly deleterious and distressing influence on the quality of life of affected individuals. To ascertain an efficacious treatment modality for this ailment, comprehensive scientific investigations have elucidated that the sigma 1 receptor represents a remarkable target for therapeutic agents. The 3D-QSAR analyses were conducted utilizi...
    Disponible

    62,13 €