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Derivados da pirimidina como inibidores do recetor σ1 humano

Derivados da pirimidina como inibidores do recetor σ1 humano

Fattouche Maroua

75,87 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Química física
ISBN:
9786200822208
75,87 €
IVA incluido
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Sobre IBD

A síndrome da dor neuropática exerce uma influência significativamente deletéria e angustiante na qualidade de vida dos indivíduos afectados. Para determinar uma modalidade de tratamento eficaz para esta doença, investigações científicas exaustivas elucidaram que o recetor sigma 1 representa um alvo notável para agentes terapêuticos. As análises 3D-QSAR foram efectuadas utilizando a metodologia Comparative Molecular Similarity Index Analysis (CoMSIA). Os resultados destas investigações corroboraram a robustez da estrutura CoMSIA na previsão precisa da bioatividade de um conjunto diversificado de compostos. No total, dezasseis novos compostos foram habilmente sintetizados para exibir uma maior eficácia contra a dor neuropática. Em conjunto com a análise abrangente 3D-QSAR, os compostos recentemente sintetizados foram submetidos a uma avaliação exaustiva com o objetivo de elucidar os seus perfis farmacocinéticos e toxicológicos, produzindo assim conhecimentos críticos para investigações prospectivas in vitro.

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Otros libros del autor

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