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Parkinson’s Disease

Parkinson’s Disease

Mona El-Banna

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9783639714111
60,14 €
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Sobre IBD

Parkinson’s disease (PD) is a common neurodegenerative disorder affecting over 10 million people worldwide, with prevalence rising with age. It is characterized by motor symptoms like bradykinesia and rigidity, and non-motor symptoms driven by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc). Key pathological features include alpha-synuclein aggregation into Lewy bodies, mitochondrial dysfunction, oxidative stress, and neuroinflammation.As PD progresses, dopamine depletion worsens, leading to advanced motor complications and non-motor impairments. Current treatments alleviate symptoms but do not prevent neurodegeneration. Understanding the mechanisms of alpha-synuclein aggregation, mitochondrial dysfunction, and neuroinflammation is essential for developing effective disease-modifying therapies.

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