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Paracetamol de qualidade farmacêutica

Paracetamol de qualidade farmacêutica

Amani Sahbani / Jamil Kraiem / Mohamed Hedi Ben Cheikh

75,94 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Química
ISBN:
9786209141065
75,94 €
IVA incluido
Disponible

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Sobre IBD

O objetivo deste projeto foi avaliar a qualidade farmacêutica de 5 lotes de paracetamol sintetizados segundo os princípios da química verde, em conformidade com as exigências da Farmacopeia Europeia. Estes lotes foram caracterizados por análises qualitativas e quantitativas: cromatografia, espetroscopia de infravermelhos e calorimetria diferencial de varrimento. Os lotes mais conformes foram submetidos a testes de estabilidade e de degradação forçada. As análises confirmaram a identidade do paracetamol sintetizado, com correlações FTIR > 98%. As purezas medidas por HPLC-DAD atingiram 77,3% e os lotes selecionados (2 e 4) respeitaram as normas da farmacopeia (doseamento: 99,6-100,8%; impurezas K < 50 ppm; perdas por secagem < 0,5%). O estudo de degradação forçada mostrou uma sensibilidade acrescida à oxidação e à hidrólise. Os resultados deste trabalho demonstraram que o paracetamol estudado estava em conformidade com as normas da Farmacopeia Europeia e sublinharam a necessidade de prosseguir os estudos de estabilidade a longo prazo.

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