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OSTEOPOROZA MENOPAUZALNA

OSTEOPOROZA MENOPAUZALNA

Nádia Pereira et al

66,91 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209395345
66,91 €
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Osteoporoza jest cichą chorobą metaboliczną kości, zwykle rozpoznawaną dopiero po pierwszym złamaniu, i staje się coraz ważniejsza ze względu na starzenie się populacji, zwłaszcza kobiet. Postać po menopauzie jest wynikiem niedoboru estrogenów spowodowanego niewydolnością jajników, co wpływa na przebudowę kości poprzez działanie na receptory obecne w osteoblastach, osteoklastach i komórkach odpornościowych. Najnowsze dowody sugerują również, że estrogeny zachowują homeostazę mikrobioty i integralność bariery jelitowej, zapobiegając stanom zapalnym i proabsorpcyjnym cytokinom. Chociaż choroba nie jest śmiertelna, znacznie obniża jakość życia i wiąże się z wysokimi kosztami. Opcje terapeutyczne obejmują leki anaboliczne, takie jak teryparatyd i romosozumab, oraz środki antyresorpcyjne, takie jak bisfosfoniany, denosumab, selektywne modulatory receptora estrogenowego, kalcytonina i terapia hormonalna. Oczekuje się opracowania innowacyjnych strategii, w tym inżynierii tkankowej i nowych celów molekularnych.

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