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Opracowanie i ocena preparatu nanotechnologicznego do leczenia ran

Opracowanie i ocena preparatu nanotechnologicznego do leczenia ran

Kavita Attri / Manvi Singh / Sonal Setya

73,52 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209862205
73,52 €
IVA incluido
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Nanostrukturalny nośnik lipidowy (NLC) zawierający CPX został z powodzeniem opracowany jako potencjalny system miejscowego dostarczania leku do leczenia ran. Lek i jego potencjalne zaróbki dla NLC zostały sprawdzone w badaniach przedformulacyjnych, takich jak ocena organoleptyczna, analiza temperatury topnienia, widma UV-Visible, badania rozpuszczalności, analiza współczynnika podziału, analiza w podczerwieni z transformacją Fouriera (FT-IR) i analiza różnicowej kalorymetrii skaningowej (DSC). Po pomyślnym scharakteryzowaniu leku, opracowano formulację w celu wyboru i optymalizacji stałego lipidu, ciekłego lipidu, stosunku stałego lipidu do ciekłego lipidu, stężenia środka powierzchniowo czynnego i współśrodka powierzchniowo czynnego, techniki formulacji, parametrów procesu, a mianowicie PDI, czasu sonikacji i EE%. Charakterystykę przygotowanych preparatów NLC oceniano za pomocą kształtu, rozkładu wielkości cząstek, analizy potencjału zeta, skuteczności uwięzienia leku i badań uwalniania leku in vitro w celu wybrania zoptymalizowanego preparatu NLC. Badanie przenikania wykazało, że parametry przepuszczalności były znacznie wyższe dla preparatu żelowego na bazie NLC w porównaniu z preparatem dostępnym na rynku.

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