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O efeito protetor da L-arginina contra a nefrotoxicidade

O efeito protetor da L-arginina contra a nefrotoxicidade

Eman Badawi El-Shal / H.A. Amin / M.H. Badawoud

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786208292355
54,06 €
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O 5-fluorouracil (5-FU) é um potente agente antineoplásico utilizado no tratamento de várias neoplasias malignas. A via do óxido nítrico (NO) da L-arginina está envolvida na patogénese da lesão renal induzida pela quimioterapia. Este trabalho investigou o mecanismo benéfico da suplementação com L-arginina na nefropatia induzida por 5 FU. Oitenta ratos Wistar machos foram divididos em quatro grupos iguais: Grupo de controlo; grupo L-arginina; grupo 5-FU e grupo L-arginina durante uma semana antes e 4 semanas concomitantemente com o grupo 5-FU. No final da experiência, as funções renais foram avaliadas e as amostras de rins foram processadas para secções de parafina e coradas com H&E, Tricoma de Masson e PAS. Demonstração imuno-histoquímica de caspase-3 para apoptose e óxido nítrico sintase induzível (iNOS). Foi utilizado um analisador de imagens para analisar os resultados morfometricamente e estatisticamente. A administração de L-arginina a animais tratados com 5-FU provocou uma redução significativa dos níveis séricos de ureia e creatinina, do volume de urina, da excreção urinária de proteínas e do rácio rim/peso corporal em comparação com o grupo tratado com fluorouracil. A L-arginina melhorou a glomerulo-celerose.

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Otros libros del autor

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    Le 5-fluorouracile (5-FU) est un puissant agent antinéoplasique utilisé pour le traitement de diverses tumeurs malignes. La voie de l’oxyde nitrique (NO) de la L-arginine est impliquée dans la pathogenèse des lésions rénales induites par la chimiothérapie. Ce travail a étudié le mécanisme bénéfique de la supplémentation en L-arginine dans la néphropathie induite par le 5 FU. Qu...
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    5-Fluorouracil (5-FU) ist ein starkes antineoplastisches Mittel, das zur Behandlung verschiedener bösartiger Tumore eingesetzt wird. Der L-Arginin-Stickoxid-(NO)-Signalweg ist an der Pathogenese von durch Chemotherapie verursachten Nierenschäden beteiligt. In dieser Arbeit wurde der positive Mechanismus der L-Arginin-Supplementierung bei 5-FU-induzierter Nephropathie untersucht...
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