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Novo andaime contra o recetor de estrogénio para inibir o cancro da mama

Novo andaime contra o recetor de estrogénio para inibir o cancro da mama

Syed Sameena

53,73 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Empresa y gestión
ISBN:
9786208711894
53,73 €
IVA incluido
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Sobre IBD

Os receptores de estrogénio (ER) estão sobre-expressos nos cancros da mama humanos e associados a tumores diferenciados com um prognóstico mais favorável. Paradoxalmente, estes receptores medeiam a ação mitogénica dos estrogénios nas células humanas do cancro da mama e a eficácia dos antiestrogénios na terapia adjuvante dos tumores primários. O modo de ação da sobreexpressão da proteína dos receptores de estrogénio (ER) desempenha um papel fundamental na origem do cancro da mama. O mecanismo exato subjacente à proteção do ER contra a progressão do cancro para metástases continua por investigar. Neste estudo, mostramos que os farmacóforos do dietilstilbestrol e de outras quatro moléculas de fármacos foram concebidos e analisados. O principal objetivo deste estudo é conceber uma nova estrutura para bloquear o recetor de estrogénio através da 'abordagem de Docagem Molecular', utilizando as ferramentas In silico. Além disso, a diversidade química e o rastreio ADME também são desejados, o que aumenta a nossa capacidade de prever e modelar os pontos finais farmacocinéticos e metabólicos mais relevantes, acelerando assim o processo de descoberta de medicamentos.

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