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Novel Pharmacological Inhibitors for Bacterial Protein Toxins

Novel Pharmacological Inhibitors for Bacterial Protein Toxins

Novel Pharmacological Inhibitors for Bacterial Protein Toxins

Holger Barth

43,75 €
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Editorial:
MDPI AG
Año de edición:
2017
Materia
Biologia, ciencias de la vida
ISBN:
9783038424307
Páginas:
284
Encuadernación:
Rústica
43,75 €
IVA incluido
Disponible

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Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication. 

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