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Разработка антидиабетической формулы с циклодекстринами

Разработка антидиабетической формулы с циклодекстринами

Васанти Суварна / Манси Чалке / Прамила Чобей

43,75 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786207884858
43,75 €
IVA incluido
Disponible

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Sobre IBD

Целью настоящего исследования было улучшение растворимости и растворения Натеглинида, плохо растворимого в воде препарата, с помощью циклодекстрина (ЦД). Бинарная система натеглинида с циклодекстрином была приготовлена различными методами. Диаграмма фазовой растворимости демонстрирует AL тип изотермы, который указывает на линейное увеличение растворимости в зависимости от циклодекстрина. Скорость растворения оказалась более эффективной при использовании метода комплексообразования распылительной сушкой по сравнению с методом физического смешивания и методом комплексообразования разминанием. Разработанная циклодекстриновая таблетированная формула натеглинида показала лучшую скорость растворения, чем рыночный продукт. Был разработан подходящий УФ-метод для исследования растворения. Разработан метод ВЭЖХ для анализа разработанной рецептуры.

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