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Neuroendokrine und neurotrophe Verbindungen zwischen Menopause und Risiko

Neuroendokrine und neurotrophe Verbindungen zwischen Menopause und Risiko

Heba Hassan / Mona El-Banna

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786202189064
105,28 €
IVA incluido
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Neurodegenerative Erkrankungen, darunter die Alzheimer- und die Parkinson-Krankheit, sind durch einen fortschreitenden Verlust von Nervenzellen gekennzeichnet, der zu kognitiven und motorischen Beeinträchtigungen führt. Diese Erkrankungen weisen deutliche geschlechtsspezifische Unterschiede in der Prävalenz und im Verlauf auf, wobei immer mehr Beweise darauf hinweisen, dass die Menopause ein entscheidender Faktor für die Anfälligkeit von Frauen ist. Der Rückgang von Östrogen, Progesteron und anderen neurotrophen Faktoren während der Menopause stört zahlreiche neuroprotektive Prozesse und trägt so zum Ausbruch und Fortschreiten der Krankheit bei.Dieses Buch beleuchtet die wichtigsten pathologischen Mechanismen, die den NDs zugrunde liegen, wie Proteinfehlfaltung, oxidativer Stress, mitochondriale Dysfunktion, Neuroinflammation, Apoptose, genetische Anfälligkeit und Beeinträchtigung der Blut-Hirn-Schranke. Es wird die modulierende Rolle der Sexualhormone und des insulinähnlichen Wachstumsfaktors 1 (IGF-1) durch genomische und nichtgenomische Signalwege hervorgehoben, die das neuronale Überleben und die Homöostase des Gehirns regulieren. Insgesamt wird die Menopause als ein entscheidender biologischer Übergang dargestellt, der die Anfälligkeit für neurodegenerative Erkrankungen erhöht, indem er die miteinander verbundenen neuroendokrinen und neurotrophen Netzwerke unterbricht.

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