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Modelowanie homologiczne ludzkiego receptora NK-1 i badanie dokowania

Modelowanie homologiczne ludzkiego receptora NK-1 i badanie dokowania

Manish K. Gupta / Viney Kumar

67,11 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209641770
67,11 €
IVA incluido
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Receptor neurokininy-1 (NK-1) reguluje wiele funkcji biologicznych związanych z rakiem, takich jak proliferacja komórek nowotworowych, angiogeneza i migracja komórek nowotworowych w celu inwazji i przerzutów. Antagoniści receptora NK-1 specyficznie hamują proliferację komórek nowotworowych, migrację komórek nowotworowych i wykazują działanie antyangiogeniczne. Dlatego też opracowanie antagonistów NK-1 do leczenia nowotworów jest obecnie przedmiotem zainteresowania. Struktura 3D NK-1 nie jest dostępna w bazie danych białek. Utrudnia to projektowanie selektywnych antagonistów NK-1. Niniejsza książka opisuje modelowanie homologiczne ludzkiego receptora NK-1 przy użyciu wielu szablonów w celu zapewnienia podstawy strukturalnej do projektowania nowych inhibitorów NK-1 i środków przeciwnowotworowych. Autorzy przewidują, że książka będzie bardzo przydatna dla naukowców zajmujących się projektowaniem i opracowywaniem antagonistów receptora NK-1 oraz środków przeciwnowotworowych.

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