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Modeling and Analysis of Signal Transduction Networks

Modeling and Analysis of Signal Transduction Networks

Modeling and Analysis of Signal Transduction Networks

Juergen Hahn

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Editorial:
MDPI AG
Año de edición:
2016
Materia
Química industrial
ISBN:
9783038421412
Páginas:
64
Encuadernación:
Cartoné

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Biological pathways, such as signaling networks, are a key component of biological systemsof each living cell. In fact, malfunctions of signaling pathways are linked to a number ofdiseases, and components of signaling pathways are used as potential drug targets. Elucidatingthe dynamic behavior of the components of pathways, and their interactions, is one of the keyresearch areas of systems biology.Biological signaling networks are characterized by a large number of components and aneven larger number of parameters describing the network. Furthermore, investigations ofsignaling networks are characterized by large uncertainties of the network as well as limitedavailability of data due to expensive and time-consuming experiments. As such, techniquesderived from systems analysis, e.g., sensitivity analysis, experimental design, and parameterestimation, are important tools for elucidating the mechanisms involved in signaling networks.This Special Issue contains papers that investigate a variety of different signaling networks viaestablished, as well as newly developed modeling and analysis techniques.

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