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Mitochondriale Biogenese in der Pathogenese der Endometriose

Mitochondriale Biogenese in der Pathogenese der Endometriose

Dr. Beeram Hima Bindu / Prof. Manjula Bhanoori

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786207729623
98,44 €
IVA incluido
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Sobre IBD

Bei der Endometriose handelt es sich um eine östrogenabhängige Erkrankung, die bei Frauen im reproduktiven Alter ein abnormales Wachstum von endometriumähnlichem Gewebe außerhalb der Gebärmutterhöhle aufweist. Schätzungen zufolge sind weltweit 5-10 % der Frauen im reproduktiven Alter davon betroffen. Eine gestörte mitochondriale Biogenese und eine durch oxidativen Stress ausgelöste Entzündungsreaktion in der Beckenhöhle werden mit der Pathogenese der Endometriose in Verbindung gebracht. Da es sich bei der Endometriose um eine mit Entzündungen und dem Energiestoffwechsel assoziierte Erkrankung handelt und die Gene TFAM, PGC-1α und VDR an der Aufrechterhaltung der mitochondrialen DNA-Integrität und Kopienzahl beteiligt sind, wird die Analyse der Polymorphismen von TFAM, PGC-1α und VDR in Bezug auf die mitochondriale DNA-Kopienzahl zum besseren Verständnis der Pathophysiologie der Endometriose beitragen.

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