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Método RP-HPLC de validação e indicação de estabilidade para cápsulas de meloxicam

Método RP-HPLC de validação e indicação de estabilidade para cápsulas de meloxicam

Adil Wali / Mubashir Masoodi

93,60 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209307867
93,60 €
IVA incluido
Disponible

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O meloxicam (4-hidroxi-2-metil-N-(5-metil-2-tiazolil)-2H-1,2-benzotiazina-3-carboxamida-1,1-dióxido) é um AINE utilizado no tratamento de doenças reumáticas, que se distingue pelo facto de ser bem tolerado pelo estômago nas doses necessárias para a terapia. As propriedades anti-inflamatórias e analgésicas do meloxicam tornam esta substância ativa muito interessante para uso na terapia da dor. O meloxicam atua como inibidor não seletivo da enzima ciclooxigenase (COX), inibindo tanto a ciclooxigenase-1 (COX-1) quanto a ciclooxigenase-2 (COX-2). Foi desenvolvido um método RP-HPLC isocrático rápido e específico para a determinação de cápsulas de Meloxicam utilizando um detetor UV/matriz de díodos. O método foi validado de acordo com as diretrizes da ICH e USP/NF. Portanto, este método pode ser útil para a análise de rotina de cápsulas de Meloxicam como medicamento a granel e forma farmacêutica.

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