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Marqueurs immuno-épidémiologiques de la transmission du paludisme au Kenya

Marqueurs immuno-épidémiologiques de la transmission du paludisme au Kenya

Guiyun Yan / Guofa Zhou / Kingsley Badu

107,92 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786209257247
107,92 €
IVA incluido
Disponible

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Les outils actuels permettant de mesurer l’intensité de la transmission du paludisme ont une sensibilité limitée lorsque la transmission est faible. Des systèmes de surveillance robustes sont nécessaires pour surveiller la réduction de la transmission et prévenir la réintroduction rapide du paludisme dans les zones en cours d’élimination. Les outils sérologiques basés sur la réponse immunitaire aux antigènes du parasite et du vecteur sont des outils potentiels pour mesurer la transmission. Cette étude a examiné les preuves sérologiques de l’exposition aux vecteurs et de l’endémicité du paludisme dans les hautes terres de l’ouest du Kenya, le long d’un gradient d’intensité de transmission. Les taux totaux d’IgG dirigés contre le MSP-119 de P. falciparum et le peptide gSG6-P1 des glandes salivaires d’Anopheles ont été mesurés dans une cohorte stratifiée par âge pendant les saisons de faible et de forte transmission du paludisme. Une analyse de régression a été effectuée pour examiner l’association entre la prévalence des anticorps et la prévalence des parasites. Les données de séroprévalence du MSP-119 spécifiques à l’âge ont été ajustées à un modèle catalytique réversible simple afin d’étudier la relation entre l’exposition au parasite et l’âge.

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