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Lipogeneza ściany tętnicy

Lipogeneza ściany tętnicy

Michel Beylot / Nadjiba Hamlat-Khennaf / Souhila Aouichat

107,94 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786209536069
107,94 €
IVA incluido
Disponible

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LIPOGENEZA ŚCIANY TĘTNICZEGO: REGULACJA JEJ EKSPRESJI I ANOMALIE W INSULINO-REZYSTANCJI I CUKRZYCIE Zbadaliśmy ekspresję i regulację lipogenezy w aortach i CMLV oraz ustaliliśmy, czy jest ona modyfikowana przez insulino-rezystancję i cukrzycę. Otyłe szczury Zucker (ZO), cukrzycowe i Psammomys obesus gromadzą więcej lipidów w aortach niż szczury kontrolne. Jednak ekspresja genów lipogenezy i genów zaangażowanych w wychwytywanie kwasów tłuszczowych nie jest zwiększona. Podobny wynik uzyskano w próbkach pobranych podczas endarterektomii u ludzi. Środowisko adipogeniczne, glukoza lub sama insulina stymulują umiarkowanie lipogenezę wyłącznie w komórkach CML kontrolnych szczurów rasy Zucker, nie zaobserwowano żadnego wpływu w komórkach CML szczurów ZO. Wykazaliśmy, że wpływ TO901317 na lipogenezę w CMLV wynika wyłącznie z aktywacji receptora jądrowego LXRα, PXR nie ma żadnego wpływu. Podsumowując, lipogeneza nie jest zwiększona w ścianie tętnicy podczas insulinooporności i cukrzycy.

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