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Jednoczesne stosowanie inhibitorów CYP w AML

Jednoczesne stosowanie inhibitorów CYP w AML

Diana Isabella Dmytrow

121,08 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786202371407
121,08 €
IVA incluido
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Retrospektywne badanie kliniczno-kontrolne przeprowadzone na wcześniej wybranej grupie n = 108 pacjentów z rozpoznaniem AML, hospitalizowanych w niemieckim szpitalu. U 59 ze 108 pacjentów z AML (54,6%) stwierdzono jednoczesne stosowanie inhibitorów CYP. 59 pacjentów z AML doświadczyło znacznie więcej (p = 0,036) zdarzeń niepożądanych (1489 z 2483, 59,9%) niż pacjenci z AML bez jednoczesnego stosowania inhibitorów CYP (994 z 2483, 40,1%). U 59 z 59 pacjentów z AML, którzy otrzymali jednocześnie inhibitory CYP, stwierdzono co najmniej jedną potencjalną interakcję z inhibitorami CYP. Kobiety wykazują znacznie więcej potencjalnych interakcji z inhibitorami CYP na dzień (0,321) i na pobyt w szpitalu niż mężczyźni (p = 0,038). 721 z 1489 zdarzeń niepożądanych (48,4%) u n = 59 pacjentów z AML było zgodnych z działaniami niepożądanymi jednocześnie stosowanych inhibitorów CYP i zostało ocenionych jako potencjalna interakcja z inhibitorami CYP. Spośród n = 108 pacjentów z AML, mniej więcej co drugi doświadczył jednoczesnego stosowania inhibitorów CYP i co najmniej jednej potencjalnej interakcji z inhibitorami CYP, w szczególności kobiety.

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