Inhibiteurs de la résorption osseuse et ostéonécrose des maxillaires

Inhibiteurs de la résorption osseuse et ostéonécrose des maxillaires

Afef Slim / Jamil Selmi / Sawssen rezgui

92,12 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
ISBN:
9786208979539
92,12 €
IVA incluido
Disponible

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Les inhibiteurs de la résorption osseuse, tels que les bisphosphonates et le denosumab, ont transformé la prise en charge de nombreuses pathologies osseuses, notamment l’ostéoporose, les métastases osseuses et certaines tumeurs malignes. Toutefois, leur utilisation est associée à un effet indésirable redouté : l’ostéonécrose des maxillaires (ONM), une complication rare mais potentiellement sévère.Ce chapitre explore les mécanismes physiopathologiques à l’origine de cette complication, les facteurs de risque (voie d’administration, durée du traitement, cofacteurs locaux comme les extractions dentaires ou infections), ainsi que les recommandations actuelles en matière de prévention, de diagnostic et de prise en charge.Une attention particulière est portée à la distinction entre les formes d’ONM selon l’indication thérapeutique (ostéoporose vs cancer), ainsi qu’aux dernières recommandations des sociétés savantes. L’approche repose sur une collaboration étroite entre le prescripteur, le chirurgien-dentiste et le patient, afin de limiter les risques tout en maintenant une qualité de vie optimale.

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