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In-silico-Ansätze für das Design von Arzneimittelkandidaten

In-silico-Ansätze für das Design von Arzneimittelkandidaten

Hamid Maghat / Mohammed Bouachrine / Youness MOUKHLISS

66,79 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209631658
66,79 €
IVA incluido
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Die Entdeckung und Entwicklung von Medikamenten ist eine kostspielige und zeitaufwändige Praxis, und Ansätze für das computergestützte Medikamentendesign werden in der Pharmaindustrie immer beliebter, um den Prozess zu beschleunigen. Mithilfe ihrer Ansätze können sich die Wissenschaftler auf die leistungsfähigsten Verbindungen konzentrieren, um die Schwierigkeiten synthetischer und biologischer Tests zu minimieren. Um diese Achse herum gliedert sich die Arbeit dieser Dissertation, deren Hauptziel es ist, neue Wirkstoffkandidaten auf Isoxazolbasis vorzuschlagen, indem sie sich einiger in-silico-Ansätze bedient wie: QSAR-Modellierung, Bewertung der pharmakokinetischen Eigenschaften und der Toxizität, Bewertung der Stabilität der Liganden-Rezeptor-Komplexe, Nachweis der Transporttunnel der Liganden, Bewertung ihrer biologischen Wirksamkeit und Vorschlag von Wegen für die Synthese. Die verschiedenen Ergebnisse bilden eine nützliche Referenzbasis für Forscher, die sich für die Bereiche Arzneimitteldesign, Bioinformatik, Arzneimitteltransportkinetik und chemische Synthese interessieren.

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