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Il ruolo dell’infiammazione nella carcinogenesi orale

Il ruolo dell’infiammazione nella carcinogenesi orale

Deepu George Mathew / Priya Thomas / SHIVANI SUNIL

138,89 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Odontología
ISBN:
9786630217728
138,89 €
IVA incluido
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L’infiammazione svolge un ruolo cruciale nella carcinogenesi orale, creando un microambiente che favorisce l’insorgenza, la progressione e la diffusione del cancro. Le condizioni infiammatorie croniche portano al rilascio continuo di citochine infiammatorie, fattori di crescita, specie reattive dell’ossigeno (ROS) e specie reattive dell’azoto (RNS). Questi mediatori causano danni al DNA, mutazioni genetiche, aumento della proliferazione cellulare, inibizione dell’apoptosi, angiogenesi ed evasione immunitaria. Le cellule infiammatorie, quali macrofagi, neutrofili e linfociti, contribuiscono ulteriormente allo sviluppo del tumore secernendo citochine quali TNF-α, IL-1, IL-6 e IL-8. Pertanto, l’infiammazione persistente agisce come forza trainante nel processo multifase della carcinogenesi orale ed è ormai riconosciuta come uno dei tratti distintivi del cancro.

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