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Heteroaromatic Lipoxin A4 Analogues

Heteroaromatic Lipoxin A4 Analogues

Colm Duffy

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Editorial:
Springer Nature B.V.
Año de edición:
2012
Materia
Bioquímica
ISBN:
9783642246319

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In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.

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Otros libros del autor

  • Heteroaromatic Lipoxin A4 Analogues
    Colm Duffy
    In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most effi...
    Disponible

    135,80 €