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Granat tunezyjski stymuluje transport glukozy do mięśni

Granat tunezyjski stymuluje transport glukozy do mięśni

Amine Ben Abdennabi

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786209539077
66,66 €
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Sobre IBD

Granat, Punica granatum, był stosowany jako lekarstwo na cukrzycę. Badania wykazały hipoglikemiczne działanie ekstraktów z granatu poprzez różne mechanizmy. Jednak do tej pory żadne badania nie wykazały wpływu granatu na transport glukozy do mięśni. Celem tego projektu jest ocena przeciwcukrzycowego działania ekstraktów z granatu na transport glukozy do komórek mięśniowych w zależności od odmiany i stadium dojrzałości owoców oraz wyjaśnienie mechanizmów działania. Wyniki wykazały, że tylko odmiana granatu Gabsi znacząco stymuluje transport glukozy w porównaniu z grupą kontrolną, nie wykazując przy tym toksyczności. Efekt ten jest bardziej wyraźny w fazie dojrzałości owoców (po 6 miesiącach) niż w fazie kwitnienia. Ponadto ekstrakt z kwiatów stymuluje niezależną od insuliny ścieżkę AMPK i zwiększa poziom ekspresji specyficznych transporterów glukozy (GLUT-4). Z drugiej strony ekstrakt z dojrzałych owoców, oprócz tych dwóch mechanizmów, silnie aktywuje również zależną od insuliny ścieżkę AKT. Podsumowując, badanie to przedstawia nowy mechanizm działania przeciwcukrzycowego granatu, który jest zależny od odmiany.

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