G-Quadruplex DNA

G-Quadruplex DNA

Peter Baumann

220,00 €
IVA incluido
Disponible
Editorial:
Springer Nature B.V.
Año de edición:
2009
Materia
Genética (no médica)
ISBN:
9781588299505
220,00 €
IVA incluido
Disponible

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Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In 'G-Quadruplex DNA: Methods and Protocols', experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, 'G-Quadruplex DNA: Methods and Protocols 'promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.

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