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Formuła i optymalizacja plastrów transdermalnych

Formuła i optymalizacja plastrów transdermalnych

Mukesh Rani / Seema Rohilla

114,50 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Farmacología
ISBN:
9786630008616
114,50 €
IVA incluido
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Lisinopril jest lekiem przeciwnadciśnieniowym wskazanym w profilaktyce nadciśnienia tętniczego, zawału mięśnia sercowego i nefropatii cukrzycowej. Jest inhibitorem konwertazy angiotensyny (ACE). Ma krótki okres półtrwania i podlega zmiennemu metabolizmowi pierwszego przejścia. Wymagane jest podawanie go dwa lub trzy razy dziennie, co skutkuje słabą zgodnością pacjenta.  W tej pracy podjęto próbę sformułowania i oceny TDDS w celu przedłużonego uwalniania lizynoprylu metodą odparowywania rozpuszczalnika. Niska masa cząsteczkowa, dobra przepuszczalność i krótszy okres półtrwania leku sprawiły, że jest on odpowiednim kandydatem do opracowania plastra transdermalnego. Głównym celem sformułowania systemu transdermalnego było wydłużenie czasu uwalniania leku, zmniejszenie częstotliwości podawania i poprawa zgodności pacjenta. Charakterystykę zgodności przeprowadzono metodą IR. Przy użyciu 32-czynnikowego projektu przygotowano dziewięć preparatów przy użyciu hydrofilowych (HPMC) i hydrofobowych (etyloceluloza) polimerów wraz z wybranym plastyfikatorem i wzmacniaczem przenikania. Membrana nośna PVA została użyta jako podłoże do nalewania roztworu polimerowego. Przygotowane plastry oceniano pod kątem wyglądu fizycznego, grubości.

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