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Entwicklung einer Formulierung für Rifaximin-Mikropartikel mit verlängerter Freisetzung

Entwicklung einer Formulierung für Rifaximin-Mikropartikel mit verlängerter Freisetzung

Kiran Bhise / Rohan Karanje

49,13 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786209314742
49,13 €
IVA incluido
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Sobre IBD

Dieses Buch befasst sich mit der Formulierung und dem Prozessdesign von Mikropartikeln mit verlängerter Wirkstofffreisetzung des BCS-Klasse-IV-Arzneimittels Rifaximin durch Cyclodextrin-Komplexierung und Verlängerung der Wirkstofffreisetzung durch eine magensaftresistente Beschichtung mit Eudragit L-100. Das Konzept der Oberflächenreaktionsmethodik wurde bei der Auswahl der optimierten Charge verwendet, die anschließend hinsichtlich verschiedener Parameter weiter bewertet wurde. Die Daten belegen eine Verbesserung der Wasserlöslichkeit von BCS-Klasse-IV-Arzneimitteln durch Cyclodextrin-Komplexe. Die Freisetzung solcher Einschlusskomplexe kann durch eine magensaftresistente Beschichtung um 8 Stunden verzögert werden.

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