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Efficacia della combinazione Pazienti con nefropatia diabetica

Efficacia della combinazione Pazienti con nefropatia diabetica

Atul Tiwari / Gaurav Kumar Sharma

66,29 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786208342418
66,29 €
IVA incluido
Disponible

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Di fondamentale importanza è l’attenzione alla prevenzione, preferibile al trattamento della nefropatia diabetica. Una volta che la nefropatia è evidente, la progressione non può essere evitata, ma solo ritardata. L’indicatore clinico più precoce del danno renale è la microalbuminuria, che deve essere controllata a intervalli regolari con test sensibili. Diversi studi dimostrano l’effetto preventivo della riduzione della glicemia sulle complicanze microvascolari del diabete, compresa la nefropatia, e costituiscono il razionale per l’enfasi sul controllo glicemico stretto piuttosto che casuale. Prima e soprattutto dopo l’insorgenza della nefropatia precoce, il controllo della pressione arteriosa è fondamentale per prevenire o rallentare la progressione del danno renale. Gli agenti di prima scelta per il trattamento della microalbuminuria sono gli ACE-inibitori. L’enalapril ha un effetto antiproteinurico indipendente dall’effetto sulla pressione arteriosa sistemica. Il trattamento con enalapril può ridurre il tasso di declino della funzione renale nei pazienti con nefropatia diabetica più di un trattamento antipertensivo altrettanto efficace con metoprololo. Ciò indica uno specifico effetto protettivo renale degli inibitori dell’enzima di conversione dell’angiotensina nella nefropatia diabetica.

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