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Effetti dei fattori neurotrofici sulla maturazione della giunzione neuromuscolare

Effetti dei fattori neurotrofici sulla maturazione della giunzione neuromuscolare

Wei Song

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208485573
82,72 €
IVA incluido
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La giunzione neuromuscolare subisce un processo di maturazione fisiologica dopo il contatto iniziale tra nervo e muscolo, caratterizzato da un aumento spontaneo dell’ampiezza della corrente sinaptica e da una diminuzione del tempo di salita, nonché dallo sviluppo di un rilascio quantico ben definito di ACh. L’applicazione cronica di BDNF e l’aumento del cAMP intracellulare hanno provocato l’inibizione del processo di maturazione, mentre NT-3, NT-4, GDNF, HB-GAM e HGF sembrano promuoverlo. La risposta al BDNF è stata mediata dal recettore TrkB. Gli inibitori della PKA potrebbero invertire gli effetti inibitori del cAMP e del BDNF, il che suggerisce che il cAMP e il BDNF sopprimono la maturazione della NMJ attraverso la via di segnalazione cAMP-PKA-dipendente. Ulteriori indagini hanno rivelato che le CaMK e il Ca2+ intracellulare mediano gli effetti inibitori del cAMP e del BDNF.

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