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Efeito dos compostos fenólicos na produção de NET

Efeito dos compostos fenólicos na produção de NET

Ikhlass Belhassen

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786207250424

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As armadilhas extracelulares de neutrófilos (NETs) são constituídas por ADN nuclear libertado, associado a histonas e proteínas granulares, que formam uma estrutura extracelular semelhante a uma rede, capaz de capturar e matar determinados micróbios. No entanto, em caso de depuração deficiente, as NET podem constituir uma fonte importante de auto-antigénios, aumentando o risco de auto-reatividade contra os seus componentes. Isto aumenta significativamente o risco de desenvolvimento de várias doenças auto-imunes, como a artrite reumatoide (AR) e o lúpus eritematoso sistémico (LES). Assim, a utilização de moléculas com elevado poder antioxidante parece ser uma via possível para minimizar o impacto deletério das NETs nos tecidos, particularmente no caso de inflamação aguda ou crónica. É neste contexto que se insere o nosso trabalho, no qual nos interessou demonstrar o poder inibitório de quatro moléculas, nomeadamente a oleuropeína, o tirosol, o tirosol3 e o fenil etanol, sobre a formação de NETs.

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Otros libros del autor

  • Effetto dei composti fenolici sulla produzione di NET
    Ikhlass Belhassen
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  • Effect of phenolic compounds on NET’s production
    Ikhlass Belhassen
    Neutrophil extracellular traps (NETs) are made up of released nuclear DNA associated with histones and granular proteins, which form a network-like extracellular structure capable of trapping and killing certain microbes.after performing their function, NETs should normally be degraded by DNAse. However, in the event of poor clearance, NETs can be a major source of autoantigens...
  • Wirkung von phenolischen Verbindungen auf die Produktion von NET’s
    Ikhlass Belhassen
    Die extrazellulären Fallen der Neutrophilen (NETs) bestehen aus freigesetzter nukleärer DNA in Verbindung mit Histonen und granulären Proteinen, die eine netzartige extrazelluläre Struktur bilden, die bestimmte Mikroben einfangen und abtöten kann.Nach Erfüllung ihrer Funktion sollten die NETs normalerweise durch DNAse abgebaut werden. Bei schlechter Clearance können NETs jedoch...
  • Effet des composés phénoliques sur la production des NET’s
    Ikhlass Belhassen
    Les pièges extracellulaires des neutrophiles (NETs) sont constitués d’ADN nucléaire libéré associé à des histones et à des protéines granulaires, qui forment une structure extracellulaire en forme de réseau capable de piéger et de tuer certains microbes.Après avoir effectué leur fonction, les NETs doivent normalement être dégradés parles DNAse. Cependant, et en cas d’une mauvai...