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Efecto de Antidepresivos sobre el Citoesqueleto Neuronal

Efecto de Antidepresivos sobre el Citoesqueleto Neuronal

Lérida Liss Flores V. / María Teresa Sepúlveda Angulo / Myrna Sabanero L.

27,55 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2013
Materia
Biologia, ciencias de la vida
ISBN:
9783659073656
27,55 €
IVA incluido
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Sobre IBD

El Desorden Depresivo Mayor (Depresión) es una alteración del sistema nervioso central caracterizado por la culminación de cambios profundos en el estado de ánimo y la regulación afectiva. Su régimen de tratamiento actual involucra la administración de inhibidores selectivos de la recaptura de serotonina como la Fluoxetina y la Venlafaxina. Recientemente, se presenta un debate considerable respecto a la efectividad de diversos fármacos incluidos los antidepresivos y sus potenciales efectos adversos sobre la arquitectura y la función neuronal. En este estudio, neuronas en cultivo fueron expuestas a Fluoxetina y Venlafaxina posteriormente se evaluaron parámetros morfológicos y estructurales. Los resultados demuestran que la exposición a los fármacos inducen cambios en la estructura y composición de las neuronas tratadas. Se propone que estudios posteriores deberán ser encaminados a la evaluación de la posible reversibilidad de estos efectos y poder contribuir al desarrollo de tratamientos fundamentalmente novedosos como aquellos que involucren terapias conductuales con enriquecimiento ambiental.

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