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Dyspersje Stałe - Podejście Do Zwiększenia Szybkości Rozpuszczania

Dyspersje Stałe - Podejście Do Zwiększenia Szybkości Rozpuszczania

Santhi Priya Nagam / Siva Krishna Pusuluri / Sreenu Thalla

58,88 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786208649814
58,88 €
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Sobre IBD

Okskarbazepina, 10,11-dihydro- 10-okso-5H-dibenz(b,f)azepino-5-karboksamid, jest lekiem przeciwdrgawkowym i stabilizującym nastrój, stosowanym głównie w leczeniu padaczki. Jest również stosowany w leczeniu zaburzeń lękowych i nastroju oraz łagodnych tików ruchowych. Okskarbazepina jest sprzedawana pod nazwą Trileptal przez firmę Novartis i dostępna w niektórych krajach jako lek generyczny. Jest prolekiem, który jest aktywowany w wątrobie do eslikarbazepiny. Jest to biały lub żółtawobiały, krystaliczny proszek, prawie bezwonny, o masie cząsteczkowej 252,268 g/mol. Okskarbazepina jest słabo rozpuszczalna w acetonie, chloroformie, dichlorometanie i metanolu. Jest praktycznie nierozpuszczalna w etanolu, eterze i wodzie. Lek wykazuje niską biodostępność związaną ze słabą rozpuszczalnością w wodzie. Okskarbazepina jest związkiem klasy II, tj. nierozpuszczalnym w wodzie, lipofilnym i wysoce przepuszczalnym zgodnie z systemem klasyfikacji biofarmaceutycznej. Celem tego badania było przygotowanie i scharakteryzowanie stałych dyspersji słabo rozpuszczalnego w wodzie leku przeciwdrgawkowego z rozpuszczalnym w wodzie nośnikiem, takim jak primogel, w celu poprawy jego właściwości rozpuszczania. Stałe dyspersje przygotowano metodą współmielenia i odparowywania rozpuszczalnika.

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