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Die antibakterielle Resistenz, was ist das?

Die antibakterielle Resistenz, was ist das?

Hisham Abdallah A. Yosef / Iman Hamed Imam Ismael / Nesrin Mahmoud Morsy Mohamed

72,33 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Química
ISBN:
9786209800870
72,33 €
IVA incluido
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Sobre IBD

Es wurde festgestellt, dass mehrere Bakterienstämme gegen mehrere Antibiotika resistent sind. Diese Bakterien werden als multiresistente (MDR) Bakterien bezeichnet. Sie werden auch als Superbugs bezeichnet. Zu den wichtigsten Superbugs gehören MDR-Pseudomonas aeruginosa , MDR-Escherichia coli , Vancomycin-resistente Enterokokken, Methicillin-resistente Staphylococcus aureus und Carbapenem-resistente Enterobacteriaceae. Die MDR-Bakterien weisen vier Hauptmechanismen für ihre Resistenz gegen Antibiotika auf. Diese Mechanismen sind die Inaktivierung oder Veränderung des Wirkstoffs, die Veränderung des Ziels oder der Bindungsstelle, die Veränderung des Stoffwechselwegs und die Verringerung der Wirkstoffakkumulation. Die Entwicklung der antimikrobiellen Resistenz nimmt ständig zu, und im Jahr 2019 starben weltweit etwa 1,27 Millionen Menschen an den MDR-Bakterien. Daher ist es dringend erforderlich, mehr Anstrengungen zu unternehmen, um die bestmöglichen Behandlungsstrategien gegen diese Superbugs zu finden. Dazu gehört die Entwicklung neuer Antibiotika mit neuartigen Wirkmechanismen wie Multi-Targeting-Antibiotika, Antibiotika-Kombinationen und Antibiotika-Adjuvantien, die gegen diese multiresistenten Stämme wirken können.

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