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Development of In-Tether Carbon Chiral Center-Induced Helical Peptide

Development of In-Tether Carbon Chiral Center-Induced Helical Peptide

Kuan Hu

245,00 €
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Editorial:
Springer Nature B.V.
Año de edición:
2021
Materia
Química orgánica
ISBN:
9789813366121

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This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein-protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely 'chiral center induced peptide helicity (CIH)'. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. 

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Otros libros del autor

  • Development of In-Tether Carbon Chiral Center-Induced Helical Peptide
    Kuan Hu
    This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein-protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely 'chiral center induced peptide helicity (CIH)'. The book demonstrates that a precis...
    Disponible

    246,36 €