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Cytotoksyczność

Cytotoksyczność

César Eduardo Delgado

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786200772589
65,49 €
IVA incluido
Disponible

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W tej książce możemy obserwować modyfikacje na poziomie molekularnym spowodowane uszkodzeniem HPV i promieniowaniem słonecznym, w szczególności promieniowaniem UV-B. Będziemy oceniać dwa bardzo ważne białka w nadmiernym wzroście komórek, takie jak P53 i czynnik E2F1, białka o dużym znaczeniu w normalnych procesach komórkowych, takich jak rak. Celem jest osiągnięcie synergii w zakresie nieco mniej inwazyjnej i nieco bardziej satysfakcjonującej terapii, a wszystko to przy użyciu niskich dawek promieniowania UV-B i leków pochodnych fluorochinolonów. Wszystko to w modelu eksperymentalnym z komórkami nowotworowymi HPV zwanymi komórkami SiHa, które przenoszą jeden z najbardziej rakotwórczych wirusów HPV znany jako HPV-16. Do najbardziej rakotwórczych należą HPV-13 i HPV-18. Mając to na uwadze, przeprowadzono badania w celu oceny, przy jakiej dawce promieniowania UV-B możemy uzyskać korzystny i nieszkodliwy wynik. Stwierdzono, że niskie dawki mogą przyczyniać się do proliferacji komórek ze znacznie lepszym efektem na poziomie komórkowym.

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