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Cytokiny

Cytokiny

Heba Hassan / Mona El-Banna

72,08 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630354669
72,08 €
IVA incluido
Disponible

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Cytokiny to małe białka regulacyjne o niskiej masie cząsteczkowej, które koordynują reakcje immunologiczne i zapalne poprzez pośredniczenie w komunikacji między komórkami immunologicznymi i nieimmunologicznymi. W zależności od pełnionych funkcji biologicznych dzieli się je na prozapalne, przeciwzapalne lub pleiotropowe. Cytokiny oddziałują poprzez specyficzne receptory na powierzchni komórek, aktywując szlaki sygnałowe, takie jak JAK/STAT, NF-κB, MAPK, PI3K/AKT i SMAD, w celu regulacji ekspresji genów, proliferacji komórek, ich różnicowania i przeżycia. Zaburzenia w sygnalizacji cytokinowej przyczyniają się do rozwoju chorób autoimmunologicznych, zapalnych, zakaźnych, metabolicznych, sercowo-naczyniowych, cukrzycowych i neurodegeneracyjnych. W związku z tym cytokiny i ich receptory stanowią ważne biomarkery oraz cele terapeutyczne w przypadku wielu zaburzeń o podłożu immunologicznym.

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