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Conceção de uma vacina quimérica contra a melioidose através da proteómica subtractiva

Conceção de uma vacina quimérica contra a melioidose através da proteómica subtractiva

Mohammad Kalim Ahmad Khan / Salman Akhtar / Shalini Maurya

72,10 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208625467
72,10 €
IVA incluido
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A proteómica subtractiva e a vacinologia inversa foram utilizadas para conceber uma vacina quimérica de múltiplos epítopos contra a melioidose, uma doença infecciosa grave causada pela bactéria multirresistente Burkholderia pseudomallei. A partir de 21 proteomas não redundantes de agentes patogénicos, foram selecionadas quatro proteínas como candidatas a vacinas com base na essencialidade, virulência, não-homologia com humanos, disponibilidade estrutural, localização subcelular e antigenicidade. Os principais complexos de histocompatibilidade de classe I, II e epítopos de células B foram previstos e avaliados quanto à imunogenicidade, solubilidade, alergenicidade e hidrofilicidade. Foi construída uma vacina quimérica utilizando os epítopos, os adjuvantes, os ligantes e as sequências PADRE. As simulações de docking e dinâmica molecular confirmaram interações entre alelos HLA e TLR4, indicando o potencial para provocar uma resposta imunitária, demonstrando a utilidade de ferramentas computacionais no desenvolvimento de vacinas contra B. pseudomallei.

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