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Citocinas

Citocinas

Heba Hassan / Mona El-Banna

72,08 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Biologia, ciencias de la vida
ISBN:
9786630352108
72,08 €
IVA incluido
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Sobre IBD

As citocinas são pequenas proteínas reguladoras de baixo peso molecular que coordenam as respostas imunitárias e inflamatórias, mediando a comunicação entre células imunitárias e não imunitárias. São classificadas como pró-inflamatórias, anti-inflamatórias ou pleiotrópicas, consoante as suas funções biológicas. As citocinas atuam através de recetores específicos na superfície celular, ativando vias de sinalização como JAK/STAT, NF-κB, MAPK, PI3K/AKT e SMAD para regular a expressão genética, a proliferação celular, a diferenciação e a sobrevivência. A desregulação da sinalização das citocinas contribui para o desenvolvimento de doenças autoimunes, inflamatórias, infecciosas, metabólicas, cardiovasculares, diabéticas e neurodegenerativas. Consequentemente, as citocinas e os seus recetores servem como importantes biomarcadores e alvos terapêuticos para inúmeras doenças mediadas pelo sistema imunitário.

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