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Choroba Parkinsona

Choroba Parkinsona

Mona El-Banna

70,90 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Biologia, ciencias de la vida
ISBN:
9786208765798
70,90 €
IVA incluido
Disponible

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Sobre IBD

Choroba Parkinsona (PD) jest powszechnym zaburzeniem neurodegeneracyjnym dotykającym ponad 10 milionów ludzi na całym świecie, a częstość jej występowania rośnie wraz z wiekiem. Charakteryzuje się objawami ruchowymi, takimi jak bradykinezja i sztywność, oraz objawami niemotorycznymi spowodowanymi utratą neuronów dopaminergicznych w istocie czarnej pars compacta (SNpc). Kluczowe cechy patologiczne obejmują agregację alfa-synukleiny do ciał Lewy’ego, dysfunkcję mitochondriów, stres oksydacyjny i neurozapalenie.W miarę postępu PD, niedobór dopaminy pogarsza się, prowadząc do zaawansowanych powikłań ruchowych i upośledzenia funkcji niemotorycznych. Obecne metody leczenia łagodzą objawy, ale nie zapobiegają neurodegeneracji. Zrozumienie mechanizmów agregacji alfa-synukleiny, dysfunkcji mitochondriów i neurozapalenia jest niezbędne do opracowania skutecznych terapii modyfikujących przebieg choroby.

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