The study reviewed the health sector challenges and progress in the CAREC region and recommends establishing a regional health coordination mechanism and developing a regional health strategy and investment framework.The strategy aims to enhance health security through regional cooperation. It has four main pillars: (i) leadership and human resource capacity, (ii) technical preparedness, (iii) surge demands and access to supplies, and (iv) vulnerable population groups and border health. It is intended as a tool to guide CAREC health cooperation, dialogue and knowledge exchange, programming and mobilize new project financing.