Inicio > Matemáticas y ciencia > Química > Badanie reaktywności aldehydu S-cis-metyloazirydynowego
Badanie reaktywności aldehydu S-cis-metyloazirydynowego

Badanie reaktywności aldehydu S-cis-metyloazirydynowego

Genevieve Canzonieri

71,96 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Química
ISBN:
9786630298543
71,96 €
IVA incluido
Disponible

Selecciona una librería:

  • Librería Samer Atenea
  • Kálamo Books
  • Librería Elías (Asturias)
  • Librería Kolima (Madrid)
  • Librería Proteo (Málaga)
Sobre IBD

W ramach tego projektu zbadano przydatność i reaktywność aldehydu S-cis-metyloazirydinowego, opracowanego w laboratorium dr. Yudina, w procesie makrocyklizacji peptydów. Znaczna część mojej pracy polegała na poszukiwaniu bardziej wydajnych, chemoselektywnych metod, zapewniających wysoką diastereoselektywność, czyli - innymi słowy - takich, w których jeden produkt powstaje w nadmiarze względem drugiego. Zamiast aldehydu azirydynowego o konfiguracji trans w czteroskładnikowej kondensacji Ugi zastosowano jego odpowiednik o konfiguracji cis. Zastosowanie aldehydu S-cis-metyloazirydinowego, izocyjanidu tert-butylowego oraz proliny - zarówno enancjomeru D, jak i L - doprowadziło do powstania jednego diastereomeru. Te wstępne wyniki wykazały, że zastosowanie aldehydu azirydinowego w konfiguracji cis było skuteczniejsze niż jego odpowiednika w konfiguracji trans. Ponadto pozwoliło to na lepsze zrozumienie mechanizmu zachodzącego podczas makrocyklizacji peptydów.

Artículos relacionados

  • Suzuki-Miyaura Cross-Coupling Reaction and Potential Applications
    Suzuki–Miyaura cross-coupling remains a powerful tool in organic synthesis for C–C bond formation and has various industrial applications, for example, the synthesis of pharmaceuticals and materials. Intensive research efforts are being made into finding ways of improving and expanding the scope of this process, and the development of more efficient catalytic systems for this e...
    Disponible

    67,89 €

  • Catalysis for Low Temperature Fuel Cells
    Today, the development of active and stable catalysts still represents a challenge to overcome in the research field of low temperature fuel cells. Operation at low temperatures demands the utilization of highly active catalysts to reduce the activation energy of the electrochemical reactions involved at the electrodes, and thus obtain practical performances and high efficienci...
    Disponible

    59,74 €

  • Trends in Microextraction Techniques for Sample Preparation
    Micro-extraction techniques in sample preparation are gaining interest among analytical chemists as they comply with green analytical chemistry demands and ensure environmental protection and public safety. Savings in cost and time are considered as valuable benefits by using novel micro-extraction approaches in sample handling. Selectivity, sensitivity and lower detection limi...
    Disponible

    59,87 €

  • Advances and Applications of Nano-antimicrobial Treatments
    Nowadays, great concerns are associated with the resistance demonstrated by many microorganisms towards the conventional antibiotic therapies. The failure of traditional antimicrobials, and the increasing healthcare costs, have encouraged scientific research and the development of novel antimicrobial agents. Particularly, there is a great deal of interest in nanotechnologies an...
    Disponible

    51,68 €

  • Handbook of Research on Uncovering New Methods for Ecosystem Management through Bioremediation
    Kajal Srivastava / Shivom Singh
    Maintaining and preserving the environment is a crucial consideration in an era where climate change and rising sea levels are common knowledge. It is important for researchers and developers alike to explore potential solutions for a steadily warming world. The Handbook of Research on Uncovering New Methods for Ecosystem Management through Bioremediation focuses on the agricul...
  • Structural Design and Properties of Coordination Polymers
    The assembly of organic ligands and metal centres yields coordination polymers, many of which find applications in conductivity, catalysis, magnetism, gas sorption, biological sensing and luminescence. The structure and topology of coordination polymers may be manipulated by changing the reaction conditions, leading to a large variety of structurally and topologically unique pr...
    Disponible

    43,77 €

Otros libros del autor

  • Exploring the reactivity of the S-cis-methylaziridine aldehyde
    Genevieve Canzonieri
    Im Rahmen dieses Projekts wurden die Eignung und Reaktivität von S-cis-Methylaziridin-Aldehyd, das im Labor von Dr. Yudin entwickelt wurde, bei der Makrozyklisierung von Peptiden untersucht. Ein Großteil meiner Arbeit bestand darin, effizientere chemoselektive Verfahren zu finden, die eine hohe Diastereoselektivität erzielen - mit anderen Worten: bei denen ein Produkt im Übersc...
    Disponible

    71,96 €

  • Análise da reatividade do aldeído de S-cis-metilaziridina
    Genevieve Canzonieri
    Este projeto analisou a utilidade e a reatividade do aldeído S-cis-metilaziridínico, desenvolvido no laboratório do Dr. Yudin, na macrociclagem de péptidos. Grande parte do meu trabalho consistiu em encontrar vias quimioseletivas mais eficientes que produzissem elevada diastereosseletividade ou, por outras palavras, em que um produto fosse formado em excesso em relação a outro....
    Disponible

    71,96 €

  • Étude de la réactivité de l’aldéhyde de S-cis-méthylaziridine
    Genevieve Canzonieri
    Ce projet a porté sur l’utilité et la réactivité de l’aldéhyde S-cis-méthylaziridine, mis au point dans le laboratoire du Dr Yudin, dans le cadre de la macrocyclisation des peptides. Une grande partie de mes travaux a consisté à mettre au point des voies chimiosélectives plus efficaces permettant d’obtenir une diastéréosélectivité élevée, c’est-à-dire qu’un produit soit formé e...
    Disponible

    71,96 €

  • Analisi della reattività dell’aldeide S-cis-metilaziridinica
    Genevieve Canzonieri
    Questo progetto ha esaminato l’utilità e la reattività dell’aldeide S-cis-metilaziridinica, sviluppata nel laboratorio del dott. Yudin, nella macrocilizzazione dei peptidi. Gran parte del mio lavoro ha riguardato l’individuazione di percorsi chemoselettivi più efficienti in grado di produrre un’elevata diastereoselettività, ovvero, in altre parole, la formazione di un prodotto ...
    Disponible

    71,90 €