Badania toksyczności norfloksacyny, fluorochinolonu, przeprowadzone na szczurach

Badania toksyczności norfloksacyny, fluorochinolonu, przeprowadzone na szczurach

Jagadeesh S Sanganal / Rashmi R / Shridhar N. B

100,09 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
ISBN:
9786630501483
100,09 €
IVA incluido
Disponible

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Sobre IBD

W badaniu ostrej toksyczności doustnej uzyskano wartość LD50 wynoszącą 4541,1067 mg/kg. W 28-dniowym badaniu podostrej toksyczności doustnej z powtarzanymi dawkami parametry hematologiczne, a mianowicie TEC, Hb, Hct i TLC, wykazały znaczny spadek poziomu w grupach poddanych działaniu leku. Podobnie parametry biochemiczne, tj. aminotransferaza asparaginianowa, aminotransferaza alaninowa, BUN i kreatynina, wykazały znaczny wzrost poziomu w grupach poddanych działaniu leku. W grupach poddanych działaniu substancji zaobserwowano znaczący spadek przyrostu masy ciała. Zwierzęta z grupy satelitarnej otrzymującej wysoką dawkę wykazały częściową poprawę pod względem parametrów hematologicznych, biochemicznych oraz przyrostu masy ciała po zaprzestaniu podawania norfloksacyny. Badanie histopatologiczne zarówno samców, jak i samic szczurów ujawniło toksyczne działanie norfloksacyny na wątrobę, nerki, serce, śledzionę i jelita. W badaniu histopatologicznym grupa satelitarna otrzymująca wysoką dawkę wykazała powrót do normy.

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