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Badania biochemiczne pacjentów z zaburzeniami ze spektrum autyzmu

Badania biochemiczne pacjentów z zaburzeniami ze spektrum autyzmu

Fadwa Khalid Tawfiq / Safaa Abdul Aziz Al-Ameen / Tareq Younis Ahmad

133,96 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
Materia
Química
ISBN:
9786630064001
133,96 €
IVA incluido
Disponible

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W odniesieniu do przyczyn zaburzeń ze spektrum autyzmu (ASD) wysunięto wiele hipotez. Badano niedobór dipeptydylopeptydazy-4 oraz powstawanie związków opioidowych, stres oksydacyjny i narażenie na czynniki toksyczne środowiska. Zbadano wiele parametrów biochemicznych, takich jak melatonina (MEL), neuroglobina (NGB), aktywność przeciwutleniająca (AOA), produkty zaawansowanego utleniania białek (AOPP), substancje reagujące z kwasem tiobarbiturowym (TBARS), tlenek azotu (NO) oraz glutation (GSH). Oszacowano również aktywność dipeptydylopeptydazy-4 (DPP-4), transferazy S-glutationowej (GST), acetylocholinoesterazy (AChE), mieloperoksydazy (MPO), estrazy arylowej oraz oksydazy ksantynowej (XO). W niniejszym badaniu wykorzystano wiele technik, takich jak HPLC, SDS-PAGE i chromatografia żelowa, strącanie białek, dializa, oznaczanie masy cząsteczkowej, oznaczanie białka całkowitego metodą Lowry’ego oraz badanie optymalnych warunków dla DPP-4 w surowicy. Przyszłe badania muszą obejmować analizę czynników genetycznych. Należy zbadać mutacje DPP-4, ASMT, MTHFR i COMT u dzieci z autyzmem, ponieważ mutacje w tych enzymach mogą mieć związek z ASD. Należy również zbadać poziom testosteronu, sekretyny i metalotioneiny w surowicy u pacjentów z ASD.

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